Prolactin and adequacy of dialysis

Hyperprolactinemia is a common endocrinal alteration in chronic renal failure, Several investigators examined the serum concentration of prolactin in patients with chronic renal failure and found it to be elevated. The aim of the study: is to evaluate the relation between adequacy of dialysis and levels of serum Prolactin in long term hemodialysis patients, in order to clarify if adequate dialysis adds a benefit in lowering Prolactin levels. Method: Thirty Patients with chronic renal failure (males aged 35 to 70) who participated in this study were maintained on hemodialysis 3 times/week, 4 hours each session. Dialyser membranes were 1.4 m low flux Baxter. Duration of dialysis was more than 5 years for all patients Results: Our study revealed a statistically significant negative correlation between serum prolactin level and URR, i.e. the better the dialysis adequacy the less the serum prolactin level. Conclusion: As increasing dialysis adequacy would improve hyperparathyroidism, erythropoietin sensitivity and clearance of uremic toxins, this could all contribute to improved prolactin profile. [Sameh Abou Zeid, Nevine Sherif, and Noha Elsheikh. Prolactin and adequacy of dialysis Cancer. J Am Sci 2016;12(9):53-55]. ISSN 1545-1003 (print); ISSN 2375-7264 (online). http://www.jofamericanscience.org. 8. doi:10.7537/marsjas120916.08.